The growth-hormone axis, explained
How GHRH analogs and GH secretagogues are used to study growth-hormone signaling.
Growth hormone (GH) is released by the pituitary gland in pulses, controlled mainly by two signals: growth-hormone-releasing hormone (GHRH), which stimulates release, and somatostatin, which inhibits it.
GHRH analogs
Sermorelin and CJC-1295 are synthetic versions of GHRH. Researchers use them to study how the pituitary responds to GHRH signaling, and how longer-acting versions change the pattern of GH release.
GH secretagogues
Ipamorelin works through a different receptor — the ghrelin receptor. It is studied as a selective secretagogue because, in animal research, it stimulated GH release with little effect on other hormones such as cortisol.
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